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The tool will help you study unknown viruses and prevent a new pandemic.
EVEscape's new AI tool is able to analyze evolutionary and biological data to predict how a virus might change to avoid the effects of the immune system. Scientists say that the tool can help in the development of vaccines and therapies for SARS-CoV-2 and other rapidly mutating viruses.
Experts from Harvard Medical School and the University of Oxford have developed EVEscape to predict new variants of viruses before they actually appear. The tool consists of two elements: an evolutionary sequence model that predicts changes that may occur with the virus, and detailed biological and structural information about the virus. Such data allows EVEscape to predict the most likely variants of the virus as it evolves.
EVEscape is based on the original model called EVE (evolutionary model of variant effect), a generative model that learns to predict protein functionality based on large — scale data from the evolution of different species.
In their study, the researchers showed that if EVEscape had been involved at the start of the COVID-19 pandemic, it would have successfully predicted the most frequent mutations and identified the most dangerous variants for SARS-CoV-2. The tool also made accurate predictions about other viruses, including HIV and influenza.
Researchers are now using EVEscape to predict future variants of SARS-CoV-2. Every 2 weeks, experts publish a rating of new options that can help scientists develop more effective vaccines and therapies. The team is also expanding its work to include more viruses. Experts note that EVEscape can be adapted to any virus, which makes it a flexible tool for combating viral diseases.
The source code for EVEscape is freely available, and scientists are already applying it to real-world data on SARS-CoV-2 to make forecasts of its development in the future. These data are regularly updated and made available to WHO and other stakeholders, helping to evaluate vaccines and therapies against current and future viral variants.
Importantly, EVEscape not only helps in predicting possible virus mutations, but also offers valuable information for creating vaccines that are resistant to virus evasion mechanisms. The technology opens up new perspectives in the fight against viral infections and creates the basis for a more effective response to future pandemics.
The study was funded by the National Institutes of Health, the Epidemic Preparedness Coalition, the Chan Zuckerberg Initiative, GSK, the UK Council for Engineering and Physical Sciences, and the Alan Turing Institute.
EVEscape's new AI tool is able to analyze evolutionary and biological data to predict how a virus might change to avoid the effects of the immune system. Scientists say that the tool can help in the development of vaccines and therapies for SARS-CoV-2 and other rapidly mutating viruses.
Experts from Harvard Medical School and the University of Oxford have developed EVEscape to predict new variants of viruses before they actually appear. The tool consists of two elements: an evolutionary sequence model that predicts changes that may occur with the virus, and detailed biological and structural information about the virus. Such data allows EVEscape to predict the most likely variants of the virus as it evolves.
EVEscape is based on the original model called EVE (evolutionary model of variant effect), a generative model that learns to predict protein functionality based on large — scale data from the evolution of different species.
In their study, the researchers showed that if EVEscape had been involved at the start of the COVID-19 pandemic, it would have successfully predicted the most frequent mutations and identified the most dangerous variants for SARS-CoV-2. The tool also made accurate predictions about other viruses, including HIV and influenza.
Researchers are now using EVEscape to predict future variants of SARS-CoV-2. Every 2 weeks, experts publish a rating of new options that can help scientists develop more effective vaccines and therapies. The team is also expanding its work to include more viruses. Experts note that EVEscape can be adapted to any virus, which makes it a flexible tool for combating viral diseases.
The source code for EVEscape is freely available, and scientists are already applying it to real-world data on SARS-CoV-2 to make forecasts of its development in the future. These data are regularly updated and made available to WHO and other stakeholders, helping to evaluate vaccines and therapies against current and future viral variants.
Importantly, EVEscape not only helps in predicting possible virus mutations, but also offers valuable information for creating vaccines that are resistant to virus evasion mechanisms. The technology opens up new perspectives in the fight against viral infections and creates the basis for a more effective response to future pandemics.
The study was funded by the National Institutes of Health, the Epidemic Preparedness Coalition, the Chan Zuckerberg Initiative, GSK, the UK Council for Engineering and Physical Sciences, and the Alan Turing Institute.
